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尿促性素(HMG,Menotrophin)

尿促性素(HMG,Menotrophin)

更新时间:2020-04-26
CAS号:9002-68-0
药典:英国药典
级别:药用级
详细描述
  • 主要销售市场:西欧,亚洲
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尿促性素(HMG)是一种从绝经后妇女的尿液中提取的无菌的糖蛋白促性腺激素。含有尿促卵泡素(FSH)和黄体生成素(LH)。 该物质具有刺激女性卵巢卵泡生长和成熟,维护和刺激男性睾丸激素产生相关的睾丸间质细胞,负责曲细精管中精子的成熟和发展的作用。

该物质具有刺激女性卵巢卵泡生长和成熟,维护和刺激男性睾丸激素产生相关的睾丸间质细胞,负责曲细精管中精子的成熟和发展的作用。用于诱导具有规则或不规则的细胞的无排卵的女性的排卵。用于刺激具有原发或继发性腺性腺功能低下症的男性的精子产生。

性状

类白色或微黄色粉末

溶解度

可溶于水

鉴别

符合规定

FSH活性

不少于200 IU-FSH/mg

LH活性

不少于200 IU-FSH/mg

FSH:LH

大约1:1

水份

不超过5.0%

残留溶剂

0.5%

细菌内毒素

不超过1.0 EU/FSH IU

异常**

阴性 100 IU/0.5ml/鼠

人类免疫缺陷病毒I型和II型抗原

阴性

乙肝病毒表面抗原

阴性

丙肝病毒抗体

阴性

Human Menopausal Gonadotropin (HMG) is a sterile preparation containing glycoprotein gonadotropin extracted from human post-menopausal urine. It contains both Follicle Stimulating Hormone (FSH) and Luteinising Hormone (LH).

The substance has the property in females of stimulating growth and maturation of ovarian follicles and property in males of maintaining and stimulating testicular, interstitial cells related to testosterone production and of being responsible for the full development and maturation of spermatozoa in the seminiferous tubules.

The substance is indicated for the induction of ovulation in the anovulatory woman with regular or irregular cells. For men, it is indicated for the stimulation of spermatogenesis in men who have primary or secondary hypogonadotropic hypogonadism.

Haoran Biopharma can supply bulk HMG with the following specifications. Products of various specifications can also be prepared according to customers' requests.

Appearance

Almost White or slightly yellow powder

Solubility

Freely soluble

Identification

Identified

FSH activity

Not less than 200 IU-FSH/mg

LH activity

Not less than 200 IU-LH/mg

FSH:LH

About 1:1

**

Not more than 5.0%

Residual Solvent

0.5%

Bacterial endotoxins

Not more than 1.0 EU/FSH IU

Abnormal toxicity

Negative at 100 IU/0.5ml/mouse

HIV I+II antibody

Negative

Hepatitis B surface antigen

Negative

HCV antibodies

Negative

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