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Epothilone B CAS 152044-54-7 
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Chemical PropertiesAppearance: white Powder Molecular Weight: 507.68 Density: 1.136 Boiling Point: 680.2°Cat760mmHg Melting Point: 95-97°C Flash Point: 365.2°C Refractive index: 1.532 Biological Activity: Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo . Usage: Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, Safety Data of 152044-54-7 |
Epothilone B埃博霉素BCAS号：152044-54-7
Epothilone B埃博霉素B分子式： C27H41NO6S
Epothilone B埃博霉素B英文名称： Epothilone B
Epothilone B埃博霉素B英文同义词： Patupilone; [1S-[1R*, 3R* (E) , 7R*, 10S*, 11R*, 12R*, 16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl) ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (1S,3S,7R,10S,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Epothilone B埃博霉素B分子量： 507.6825
Epothilone B埃博霉素B沸点： 680.188°C at 760 mmHg
Epothilone B埃博霉素B密度： 0mmHg at 25°C
Epothilone B埃博霉素B闪点： 365.165°C
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