Dha-K63-Diubiquitin

MQIFVKTLTG    KTITLEVEPS    DTIENVKAKI    QDKEGIPPDQ QRLIFAGKQL    EDGRTLSDYN   IQKESTLHLV     LRLRGG

Ubiquitination is a posttranslational modification (PTM) which  targets proteins for a variety of processes, such as proteasomal  degradation, ER-associated degradation and intracellular traffficking. The ubiquitin (Ub) monomers form a chain in which  its C-terminal Gly can be linked to any of the seven available Lys  side chains or the N-terminus of the preceding Ub, yielding  a large diversity of polyUb chains. Dha-based diubiquitin probes are highly useful in probing the deubiquitinase (DUB) activity and ubiquitin chain linkage specificity