货号:S19308 品牌:SINCO 英文名称:Sacubitril Impurity 42 CAS#:128779-47-5 分子式:C20H23NO4 分子量:341.41 纯度:95% HPLC 用途:Suitable for drug research, development, production, and application. Sinco Pharmachem (SINCO) specializes in providing complex organic small molecule compounds, impurity reference materials, API standards, and stable isotopes to scientists in the field of chemical drugs. SINCO has produced over 30000 products and is exported to over 40 countries worldwide, serving customers including biotechnology companies, drug manufacturing enterprises, universities, and various scientific research institutions worldwide. SINCO has always been customer-oriented, relying on scientific management methods and international scientific research technology to fully help customers obtain high-quality products and services at reasonable prices, and create excellent value for customers.

AHU377和血管紧张素IIAT1受体拮抗剂缬沙坦以1:1的摩尔比组成LCZ696， LCZ696属于血管紧张素II(AT2)受体和脑啡肽酶(Neprilysin)受体双重抑制剂，其降压效果要优于标准降压药物，是一种新型治疗心力衰竭的药物。AHU377是一种前体药物,它可以转换为酶LBQ657的活动形式。目前该药里程碑III期疗效和安全性超越临床标准药物依那普利。 该药物临床试验中，针对一个双盲二期试验患者的轻度至中度高血压，对其用于100至400毫克的剂量组合药物，80至320毫克的缬沙坦，200毫克的neprilysin抑制剂或安慰剂。组合药物的效果比仅与缬沙坦等药物效果更为显著，且耐受性良好，无血管性水肿的报告。 LCZ696从治疗早期便表现出了可持续的治疗利益：（1）心血管疾病死亡风险降低20%（p=0.00004）；（2）心脏衰竭住院率降低21%（p=0.00004）；（3）全因死亡风险降低16%（p=0.0005）；（4）总体而言，综合衡量心血管死亡或心脏衰竭住院主要终点，风险降低20%（p=0.0000002）。 该中间体化学纯度>98%，手性纯度>99%。

中文名字：N-叔丁氧羰基-3-(4-联苯基)-D-丙氨酸  CAS:128779-47-5