Fingolimod hydrochloride是鞘氨醇1-磷酸 (S1P)拮抗剂，在K562和NK细胞中的IC50 为0.033 nM。

原料药

298% min

盐酸芬戈莫德

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 For more about us , please visit our site: https://afinechem.en.alibaba.com or https://afinepharm.en.alibaba.com/   Fingolimod hydrochloride(4-fingolimod intermediate),CAS:162359-56-0 ,active pharmaceutical ingredient        FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).