脂质体挤出仪25-20（脂质体挤出器）

主要应用

The main application

• 阿霉素脂质体 

Liposome doxorubicin

• 两性霉素 B 脂质体 

Amphotericin B liposome

• 紫杉醇脂质体

Paclitaxel liposomes

• 奥沙利铂脂质体

Oxaliplatin liposomes

• 伊立替康脂质体

Irinotecan liposome

• SiRNA 脂质体

SiRNA liposome

• 白蛋白紫杉醇纳米粒

Albumin paclitaxel nanoparticles

• 核酸类脂质体 

Nucleic acid liposome

• 其他整粒脂质体样品

Other whole li posome samples

挤出原理

Technical features

脂质体挤出的原理在于，通过一定的挤出动力源将脂质体样品粒子进行挤压，使其在一定压力条件下通过 PC滤膜， 此压力作为粒子过膜过程中的剪切力可使其达到粒径控制的效果。不论形态、大小和分布都可得到极大改善。 

The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.

支撑板和滤板主要起到支撑滤膜的作用。 由于磷脂有一定的相变温度，所以在挤出之前需要对挤出器夹套通入恒温水进行预热至一定温度（50~60℃），且在使用过程中需保持在此温度。通常的脂质体品种挤出之后粒径能达到 100nm以下，PDI 能控制在 0.1 以下。

The support plate and the filter plate mainly play the role of supporting the filter membrane.Because of phospholipids have certain phase change temperature before extrusion need access to extruder jacket thermostatic water preheated to a certain temperature (50 ~ 60 ℃), and needs to keep the temperature in the process of use.The particle size of the normal liposome can reach below 100nm after extrusion, and the PDI can be controlled below 0.1.

动力源：氮气

Power source: nitrogen

技术特征

Technical features

核心部件 The core components

• 支撑板（SS316L不锈钢）

Support plate (SS316L stainless steel)

• 滤板（SS316L不锈钢）

Filter plate (SS316L stainless steel)

• 滤膜:PC材质（聚碳酸酯）

Filter membrane :PC material (polycarbonate)

• 密封系统：PU材质/聚四氟乙烯

Sealing system: PU material/polytetrafluoroethylene

• 温控系统：夹套控温水

Temperature control system: jacket control warm water

技术特点 Technical characteristics

• 单次样品量少

Low sample consumption

• 压力高

High extrusion pressure

• 残留量为"0"

No residue

• 无需手动操作

No manual operation required

• 全程可控温

Whole process temperature control

• 所有部件包括“O”型圈，垫圈均通过FDA 认证 

All parts including "O" rings, gaskets are FDA approved

• 装卸方便，便于清洗和灭菌 

Easy loading and unloading, easy cleaning and sterilization

• 所有数据可直接放大 

All data can be directly amplified

• 可用于高浓度样品处理 

Can be used for high concentration sample processing

• 可放在洁净室中使用，符合 GMP 标准 

Can be used in a clean room, in line with GMP standards

技术参数

Technical Parameter