Hydrochlorothiazide Tablets 12.5mg
| Specification | 100 tablets/ box |
| Shelf life | 3Years |
| Storage | Store below 30°C |
Therapeutic indications
Edema diseases excrete excess sodium and water from the body, reduce extracellular fluid volume, and eliminate edema. Common ones include congestive heart failure, cirrhosis ascites, nephrotic syndrome, acute and chronic nephritis edema, early stage of chronic renal failure, and sodium and water retention caused by adrenocortical hormone and estrogen treatment.
Dose and method of administration
1. Take the usual dosage orally for adults.
To treat edema, take 25-50mg each time, 1-2 times a day, or every other day, or take it 3-5 days a week.
To treat high blood pressure, take 25 to 100 mg per day, divided into 1 to 2 times, and adjust the dose according to the antihypertensive effect.
2. Take the usual dosage orally for children.
Take 1 to 2 mg/kg of body weight or 30 to 60 mg/m2 of body surface area in 1 to 2 times a day, and adjust the dose according to the efficacy. The dose for infants less than 6 months old can be up to 3 mg/kg per day.
Contraindications
Anuria.
Hypersensitivity to this product or to other sulfonamide-derived drugs.
Special warnings and precautions for use
Use with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Thiazides may add to or potentiate the action of other antihypertensive drugs.
Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma.
The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.
Lithium generally should not be given with diuretics.
Interaction with other medicinal products and other forms of interaction
When given concurrently the following drugs may interact with thiazide diuretics.
Alcohol, Barbiturates, or Narcotics
Potentiation of orthostatic hypotension may occur.
Antidiabetic Drugs (Oral Agents )
Dosage adjustment of the antidiabetic drug may be required.
Other Antihypertensive Drugs
Additive effect or potentiation.
Cholestyramine and Colestipol Resins
Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively.
Corticosteroids
Intensified electrolyte depletion, particularly hypokalemia.
Pressor Amines (e.g., Norepinephrine)
Possible decreased response to pressor amines but not sufficient to preclude their use.
Fertility, pregnancy and lactation
1. Can pass through the placental barrier. It has no preventive effect on hypertensive syndrome. Therefore, pregnant women should use it with caution.
2. Breast-feeding women should not take it.
PHARMACOLOGICAL PROPERTIES
Effect on water and electrolyte excretion.
1.Diuretic effect, increase urinary ion excretion of sodium, potassium, chloride, phosphorus and magnesium, while decreasing urinary calcium excretion. The mechanism of action of this class of drugs mainly inhibits the reabsorption of sodium chloride by the anterior segment of the distal tubule and the proximal tubule (with a lighter effect), thereby increasing the Na+-K+ exchange between the distal tubule and the collecting duct, and increasing K+ secretion. Its mechanism of action is not fully understood. This class of drugs can inhibit carbonic anhydrase activity to varying degrees, so it can explain its effect on the proximal tubules. This class of drugs can also inhibit the activity of phosphodiesterase, reduce the uptake of fatty acids by the renal tubules and the oxygen consumption of mitochondria, thereby inhibiting the active reabsorption of Na+ and Cl- by the renal tubules.
2.Antihypertensive effect. In addition to the diuretic and natriuretic effect, there may be extra-renal mechanisms involved in lowering blood pressure, which may increase the excretion of Na+ from the gastrointestinal tract.
Packaging & Shipping
| Comercial Packing | 100's/Box or Customized |
| Production Time | About 30-60days after artwork confirmed |
