Chemical Properties
Appearance:
White Solid
Molecular Weight:
414.49
Density:
1.31g/cm3
Boiling Point:
597.9°Cat760mmHg
Melting Point:
241-243oC
Flash Point:
259.5°C
Refractive index:
1.587
Solubility:
Very slightly soluble in **, with its solubility essentially pH dependent
In **, 2.1X10-3 mg/L at 25 deg C (est)
Biological Activity:
Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .
Usage:
Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoi
Safety Data of 107724-20-9
|
