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The active drug substance Omega-3-acid ethyl esters 90 are obtained by transesterification of the body oil obtained from fish of families as Engraulidae; and subsequent purification processes including KinOmega Proprietary 3 Times Molecular Distillation. It is used as a health product in prevention and cure of heart and brain blood disease, and relieving rheumatoid arthritis symptom. The major components are EPA EE and DHA EE: