尿促卵泡素（FSH）是一种来源于人类和其他动物的激素。是由垂体前叶的促性腺细胞合成和分泌的。FSH调节人体的的发展，生长，青春期发育和生殖的过程。FSH刺激男性和女性生殖细胞的成熟。FSH诱导男性睾丸支持细胞分泌抑制素，并促使睾丸支持细胞之间紧密结合。FSH促进女性卵泡的生长，尤其影响颗粒细胞。随着抑制素B的增加，FSH水平在晚卵泡期下降。只选择最*先*进的卵泡进行排卵是关键的。在黄体期结束时，FSH有轻微的上升，这似乎对开始下一个排卵周期很重要。
|
性状 |
类白色或微黄色粉末 |
|
溶解性 |
可溶于水 |
|
FSH活性 |
不少于200 IU/mg |
|
FSH:LH |
大约60:1 |
|
水份 |
不超过5.0% |
|
细菌内毒素 |
不超过0.4 EU/FSH IU |
|
人类免疫缺陷病毒I型和II型抗原 |
阴性 |
|
乙肝病毒表面抗原 |
阴性 |
|
丙肝病毒抗体 |
阴性 |
Follicle-stimulating hormone (FSH) is a hormone found in humans and other animals. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body.
In both males and females, FSH stimulates the maturation of germ cells. In males, FSH induces Sertoli cells to secrete inhibin and stimulates the formation of sertoli-sertoli tight junctions. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B, FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle.
Haoran Biopharma can supply bulk FSH with the following specifications. Products of various specifications can also be prepared according to customers' requests.
|
Appearance |
Almost White or slightly yellowish powder |
|
Solubility |
Soluble in water |
|
FSH activity |
Not less than 200 IU /mg |
|
FSH:LH |
About 60:1 |
|
Water |
Not more than 5.0% |
|
Bacterial endotoxins |
Not more than 0.4 EU/FSH IU |
|
HIV I+II antibody |
Negative |
|
Hepatitis B surface antigen |
Negative |
|
HCV antibodies |
Negative |
