Tetracycline HCL

更新时间：2020-05-18

CAS号：64-75-5

药典：中国药典,美国药典,英国药典,欧洲药典,日本药典

级别：Pharma grade, Veterinary Grade

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Tetracycline Hcl	CAS:64-75-5
	MF: C₂₂H₂₄N₂O_8.HCl	MSDS and COA: Aviable
	MW: 480.90	EINECS: 200-593-8
Description:	1. Tetracycline hydrochloride is a type of broad-spectrum antibiotics 2.Tetracycline hydrochloride can be used for bacillary dysentery (bacillary dysentery), trachoma, whooping cough, purulent meningitis, peritonitis, pneumonia, osteomyelitis. Scarlet fever, typhus, urinary tract infections, skin infections, otitis media, amoebic dysentery, biliary tract infections, intestinal infections, sepsis and so on 3. Tetracycline hydrochloride can be used in penicillin-resistant strains of infections, penicillin allergy

Certificate of Analysis

Tests	Specification		Results
	BP	EP
Characters	Yellow crystalline powder	Yellow crystalline powder	Yellow crystalline powder
	Soluble in **, slightly soluble in ethanol(96%),practically insoluble in acetone	Soluble in **, slightly soluble in ethanol(96%),practically insoluble in acetone	conforms
Identification
A.TLC	Conforms to the reference		Positive reaction
B.Color reaction	To about 2mg add 5ml of sulphuric add the solution to 2.5ml of **, the color becomes yellow		Positive reaction
C. Chlorides	Reactions of chlorides		Positive reaction
Acidity(PH)	1.8-2.8		2.29
Specific optional rotation(dried)	-240°~-255°		246°
Loss on drying	≤2.0%		0.19%
Heavy metals	Not more than 50ppm		<40ppm
Sulphated ash	≤0.50%		0.04%
Related substances
4-epitetracycline	≤3.0%		1.50%
4-epianhydrotetracycline	≤0.50%		ND
anhydrotetracycline	≤0.50%		0.12%
2-acetyl-2-decarbamoyltetracycline	≤1.50%		0.56%
Assay	95%-102.0%		97.80%
Residual solvent
Acetone(GC)	≤100ppm		23ppm
n-butanoL(GC)	≤3000ppm		1960ppm
Microbiological examination
TAMC	≤1000cfu/g		<10cfu/g
TYMC	≤100cfu/g		<10cfu/g
E. coli.	absense		absense
Conclusion	The results conform with the specifications.

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