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双咪唑

中文名称

2-正丙基-4-甲基-6-(1'-甲基苯并咪唑-2-基)苯并咪唑

中文别名

双咪唑

英文名称

2-N-PROPYL-4-METHYL-6-(1'-METHYLBENZIMIDAZOL-2-YL)BENZIMIDAZOLE

英文别名

2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazole; Bis-Benzoimidazole 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl) _benzimidazole; 2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl)benzimidazole; 2-n-Propyl-4-Methyl-6-(1-Methyl Benzimidazole-2-yl)-Benzimidazole; 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole; 2-n-Propyl-4-methyl-6-(1'-methylbenzimidazole-2-yl)benzimidazol; 2-n-propyl-4-methyl-6-(methylbenzimidazol-2-yl) benzimidazole; Double benzimidazole; 1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole; 1,7'-Dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole; 2-N-Propyl-4-Methyl-6-(1-Methyl Benzimidazole-2-yl) Benzimidazole; 1H-BENZIMIDAZOL-2-N-PROPYL-4-METHYL-6-(1-METHYL BENZIMIDAZOL)-2-YL

CAS

152628-02-9

分子式

C19H20N4

分子量

304.3889

说明书

中文全称：2-正丙基-4-甲基-6-(1'-甲基苯并咪唑-2-基)苯并咪唑，英文全称：2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole，CAS No. 152628-02-9，合成降压药替米沙坦（CAS No. 144701-48-4）的关键中间体。

作用

由单咪唑酸（7-甲基-2-丙基-3H-苯并咪唑-5-羧酸，CAS No.152628-03-0）与在多聚磷酸作用下与N-甲基邻苯二胺盐酸盐（CAS No.25148-68-9）环合制备。双咪唑与4’ -溴甲基-联苯基-2-羧酸酯进行亲核取代反应制备替米沙坦。