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低分子量肝素(LMW-Heparine)

低分子量肝素(LMW-Heparine)

更新时间:2020-04-26
CAS号:9041-08-1
药典:英国药典,欧洲药典
级别:药用级
详细描述
  • 主要销售市场:西欧,亚洲
  • 提供样品:
产品描述:

低分子量肝素由天然肝素分离或是降解得到。临床用于预防手术后血栓栓塞、预防深静脉血栓形成、肺栓塞、血液透析时体外循环的抗凝剂、末梢血管病变等。

低分子量肝素是低分子量肝素钠盐,通过从猪肉肠道粘液中分离肝素的硝基酸脱聚而获得。作为一种新的抗血栓类,低分子量肝素钠在预防或**剂量下施用时提供立即和持续的抗血栓活性。它用于预防血液透析期间凝血和预防深静脉血栓(DVT)。浩然生物制药可供应具有以下规格的散装低分子量肝素钠。各种规格的产品也可以根据客户的要求进行准备。

Dalteparin Sodium (Low Molecular Weight Heparin Sodium) (LMWH-Na) is the sodium salt of Low Molecular Weight Heparin obtained by nitrous acid depolymerization of heparin from pork intestinal mucosa.

As a new antithrombotic class, Dalteparin Sodium provides immediate and sustained antithrombotic activity when administered in prophylactic or therapeutic dosage. It is indicated for prevention of clotting during hemodialysis and prophylaxis of Deep Venous Thrombosis (DVT).

Haoran Biopharma can supply bulk Dalteparin Sodium with the following specifications. Products of various specifications can also be prepared according to customers' requests.

Appearance

White or almost white powder

Clarity of solution

Clear

Anti-factor Xa activity

110AXa IU/mg ~ 210AXa IU/mg

Anti-factor IIa activity

35 AIIa IU/mg-100 AIIa IU/mg

The ratio of anti-factor Xa to anti-factor IIa

1.9 ~ 3.2

Sodium

9.5% ~ 12.5%

Range of molecular weight

<3000: Not more than 13.0%

>8000: 15.0% ~ 25.0%

Mass-average molecular mass

5600 ~ 6400

pH

5.5 ~ 8.0

Nitrite

Not more than 5ppm

Nitrogen

1.5% ~ 2.5%

Heavy metals

Not more than 30ppm

Loss on drying

Not more than 5.0%

Nucleotide and protein impurities of the source material

Pass

Boron

Not more than 1ppm

Bacterial endotoxins

Not more than 0.01IU/AXaIU

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